Calocurb^® CLINICAL is a practitioner-exclusive supplement that supports appetite control by working with the body’s natural hormonal signals. It features Amarasate^®, a clinically studied extract of New Zealand bitter hops, delivered in a delayed-release capsule designed to reach the small intestine where it activates bitter taste receptors. This triggers the release of key satiety hormones including GLP-1, CCK and PYY, which work together to significantly reduce hunger, cravings, and caloric intake. Fast-acting and plant-based, Calocurb^® CLINICAL offers a targeted, science-driven approach to supporting healthy weight management.

• Reduces Appetite and Food Cravings
• Supports Long-Term Weight Management
• Stimulates Natural GLP-1, CCK and PYY Release
• Complements Lifestyle and Pharmaceutical Weight Loss Strategies
• Enhances Adherence to Intermittent Fasting and Time-Restricted Eating

Successful weight management is now a global health concern as more than 43% of adults are categorized as overweight or obese. Long term weight management requires lifestyle modification but often includes higher-force interventions such as pharmaceutical or surgical care. Pharmaceutical interventions are usually designed to reduce food intake by manipulating appetite; however, these interventions have long-term feasibility or safety concerns. Naturally derived compounds, with favorable safety profiles and the ability to powerfully suppress appetite and cravings, represent an appealing option for ongoing weight management.

Appetite regulation is orchestrated by a complex network of physical and chemical signals, with enteroendocrine hormones serving as some of the most powerful drivers of hunger and satiety. Under normal physiology, orexigenic hormones such as ghrelin rise during fasting and between meals, while anorexigenic hormones including GLP-1, CCK and PYY are released after eating. Specialized enteroendocrine cells in the gastrointestinal tract release these hormones in a dose- and time-dependent manner in response to nutrient intake.